recombinant human adamts1 2197 ad  (R&D Systems)

Journal: Critical Care Explorations

Article Title: Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

doi: 10.1097/CCE.0000000000000569

Figure Lengend Snippet: Cohort 2; A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 (ADAMTS-1) levels in controls and patients. Patients are further split into pathogen groups; Neisseria meningitidis (Nm; median, 7.0 pg/mL; interquartile range [IQR], 7.0–165 pg/mL; p < 0.001), Streptococcus pneumoniae (Sp; median, 7.0 pg/mL; IQR, 7.0–48 pg/mL; p = 0.08), Staphylococcus aureus (Sa; median, 7.0 pg/mL; IQR, 7.0–80 pg/mL; p = 0.02), and group A streptococcus (GAS; median, 26.5 pg/mL; IQR, 7.0–249; p < 0.001). Bar indicates median value, and whiskers indicate IQRs. Y -axis (ADAMTS-1 level) has a logarithmic scale (* p ≤ 0.05, *** p ≤ 0.001).

Article Snippet: ADAMTS-1 levels were measured with a custom-made Luminex assay based on a capture antibody, detection antibody, and recombinant human ADAMTS-1 (ADAMTS-1 DuoSet ELISA assay; R&D Systems, Abingdon, United Kingdom).

Techniques:

Journal: Critical Care Explorations

Article Title: Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

doi: 10.1097/CCE.0000000000000569

Figure Lengend Snippet: Cohort 2; A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 (ADAMTS-1) by mortality. A , ADAMTS-1 levels in survivors and nonsurvivors. B , ADATMS-1 levels in survivors and nonsurvivors of invasive infections with Neisseria meningitidis (Nm; survivors: n = 76, median 7.0 pg/mL, interquartile range [IQR] 7.0–111 pg/mL; nonsurvivors: n = 7, median 688 pg/mL, IQR 120–4,108 pg/mL; p < 0.001), Streptococcus pneumoniae (Sp; survivors: n = 56, median 7.0 pg/mL, IQR 7.0–43 pg/mL; nonsurvivors: n = 7, median 7.0 pg/mL, IQR 7.0–371 pg/mL; p = 0.42), Staphylococcus aureus (Sa; survivors: n = 46, median 7.0 pg/mL, IQR 7.0–76 pg/mL; nonsurvivors: n = 4, median 209 pg/mL, IQR 26–384 pg/mL; p = 0.07), and group A streptococcus (GAS; survivors: n = 41, median 24 pg/mL, IQR 7.0–175 pg/mL; nonsurvivors: n = 3, median 1,793 pg/mL, IQR 257–20,052 pg/mL; p = 0.008). Bar indicates median value, and whiskers indicate IQRs. Y -axis (ADAMTS-1 level) has a logarithmic scale (** p ≤ 0.01, *** p ≤ 0.001).

Article Snippet: ADAMTS-1 levels were measured with a custom-made Luminex assay based on a capture antibody, detection antibody, and recombinant human ADAMTS-1 (ADAMTS-1 DuoSet ELISA assay; R&D Systems, Abingdon, United Kingdom).

Techniques: